Postal address: Akademiska sjukhuset ing 70, 1 tr, SE-751 85, Uppsala, Sweden
Visiting address: Uppsala University Hospital, entrance 70, 1st floor
Web page: http://www.surgsci.uu.se/
Contact person: Professor Olle Nilsson, Head of department; phone: +46 (0)18 611 44 69
The Division of Anaesthesiology, Intensive care medicine and Pain treatment is part of the Department of Surgical Sciences at Uppsala University, and many of its activities are placed at the Uppsala University Hospital. The research at the Department of Surgical Sciences is conducted with surgery as a topic in the broad sense where various research teams explore different aspects of surgery in accordance to the surgical work division as done at the Uppsala University Hospital.
South Asia related research and education
Professor Lars Wiklund at the department is one of the leading Swedish researchers in the field of Anestaesiology and Intensive Care Medicine.
Lars Wiklund and his research group are currently involved in an India related research project on ”Central Nervous System (CNS) Injury and Repair”. The research team on the Swedish side also consists of Professor Sten Rubertsson, Associate Professor Hari Shanker Sharma, Associate Professor Cecile Martijn, Associate Professor Adriana Miclescu, and Associate Professor Egidijus Semenas. On the Indian side, the main collaboration partner is Dr. Ranjana Patnaik at the School of Biomedical Engineering, Department of Biomaterials, Banaras Hindu University (BHU), Varanasi. The project duration is 4 years (2010-2013) and it has annual budget of 50 000 SEK and 900k Indian Rs. (117 KSEK).
Abstract: In this project the researchers are especially interested in central nervous system (CNS) injury as an effect of ischemia and reperfusion. They are both working experimentally and clinically seeking new and more effective treatments especially after cardiac arrest. Animal experiments are combined with general physiological measurements of circulatory variables, blood gases and transport of oxygen and carbon dioxide as well as the effects of nitric oxide. We combine these more traditional measurements with studies of tissue biopsies using many techniques of analytical chemistry, histochemistry, immunochemistry and molecular biology. They study effects of drugs and methods used for re-establishment of spontaneous circulation, and also investigate methods and pharmaceuticals aiming at mitigation of the cerebral injury e.g. induced mild hypothermia and pharmaceuticals that possess neuroprotective effects or add to the therapeutical effects of hypothermia.